The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
Identifieur interne : 000016 ( France/Analysis ); précédent : 000015; suivant : 000017The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
Auteurs : B. Coutard [France] ; C. Valle [France] ; X. De Lamballerie [France] ; B. Canard [France] ; N. G. Seidah [Canada] ; E. Decroly [France]Source :
- Antiviral Research [ 0166-3542 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Furin, Spike Glycoprotein, Coronavirus.
- chemistry : Betacoronavirus.
- Amino Acid Sequence, Genome, Viral, Protein Conformation.
- mix :
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
Url:
DOI: 10.1016/j.antiviral.2020.104742
PubMed: 32057769
PubMed Central: 7114094
Affiliations:
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PMC:7114094Le document en format XML
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De Lamballerie</name><affiliation wicri:level="3"><nlm:aff id="aff1">Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Canard, B" sort="Canard, B" uniqKey="Canard B" first="B." last="Canard">B. Canard</name><affiliation wicri:level="4"><nlm:aff id="aff2">Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Seidah, N G" sort="Seidah, N G" uniqKey="Seidah N" first="N. G." last="Seidah">N. G. Seidah</name><affiliation wicri:level="1"><nlm:aff id="aff3">Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7</wicri:regionArea><wicri:noRegion>H2W1R7</wicri:noRegion></affiliation></author><author><name sortKey="Decroly, E" sort="Decroly, E" uniqKey="Decroly E" first="E." last="Decroly">E. Decroly</name><affiliation wicri:level="4"><nlm:aff id="aff2">Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Betacoronavirus (chemistry)</term><term>Furin (chemistry)</term><term>Genome, Viral</term><term>Protein Conformation</term><term>Spike Glycoprotein, Coronavirus (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Conformation des protéines</term><term>Furine ()</term><term>Glycoprotéine de spicule des coronavirus ()</term><term>Génome viral</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Furin</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Genome, Viral</term><term>Protein Conformation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Conformation des protéines</term><term>Furine</term><term>Glycoprotéine de spicule des coronavirus</term><term>Génome viral</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="mix" xml:lang="en"><term>2019-nCoV</term><term>Antivirals</term><term>Furin</term><term>Maturation protease</term><term>SARS-CoV</term><term>Spike protein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anderson, E D" uniqKey="Anderson E">E.D. Anderson</name></author><author><name sortKey="Thomas, L" uniqKey="Thomas L">L. Thomas</name></author><author><name sortKey="Hayflick, J S" uniqKey="Hayflick J">J.S. Hayflick</name></author><author><name sortKey="Thomas, G" uniqKey="Thomas G">G. Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bassi, D E" uniqKey="Bassi D">D.E. 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Decroly</name><name sortKey="Valle, C" sort="Valle, C" uniqKey="Valle C" first="C." last="Valle">C. Valle</name></country><country name="Canada"><noRegion><name sortKey="Seidah, N G" sort="Seidah, N G" uniqKey="Seidah N" first="N. G." last="Seidah">N. G. Seidah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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